Monday, August 20, 2012

Knowledge

Once Einstein was asked how many feet are in a mile. He said, "I don't know. Why should I dump my brain with the facts I can find in two minutes in any standard reference book?" Was he an Einstein because he didn't know that, or despite not knowing that?
 
Surya asked a young girl at Vijay TV show, "What is the name of the lady who killed Rajiv Gandhi?" She answered, "Priyanka... Chopra".
 
Both Einstein and the young girl are entitled to have the legitimate excuse - why to store unnecessary facts in brain that are available in the books.
 
Knowledge helps, but knowledge alone does not help. Otherwise, G.S. Pradeep, the grandmaster, should have found his name in the list of Nobel laureates, not in the Limca book of records. 

Sunday, August 19, 2012

No Rules

I think we don't have to understand chaos theory for we feel it every moment. Nothing in this universe exists on its own. Everything is connected with each other. It could be a physical connection or simply through gravity. However, the complexity of these connections is so high that we cannot predict the impact of these connections for sure. 

For example, I am sitting here. I am connected directly with the chair (which in turn is connected with the floor and the floor is connected.....), the air I inhale, the light I see, the object I touch and so on. The chair, the air and the object are composed the millions of particles and atoms which are interconnected. The light is composed of photons or EM waves - only god knows what exactly is. The chair in which I am sitting suddenly collapses - apparently because it is quite old. But why should it fall down exactly at this moment? Could I have predicted this by measuring its age, tensile strength, shear, my weight, etc? Impossible. Perhaps I could at the most have predicted that it is 'likely' to collapse any time from this day to another three years, but never the exact time. Why? Because it depends on many other 'connections' whose impact I will never be able to calculate. If I start measuring I will see only a chaos. May be finally just a simple jerk of an atom in the chair at the 'right' time has lead to the collapse. 

Poet Iqbal wrote, "Who knows? Plucking a flower in my garden may cause a star in the sky to burst". True. Each action in this universe will have some impact and initiate a chain of actions. That is how the whole universe functions. To say mathematically, try drawing two lines originating from a dot with the deviation of just 0.1 degree from each other. As the length of the lines increase you will see a wide gap between both the lines. Though the initial gap is just one or two millimetres, it may lead to kilometres distance between the lines if you keep extending the lines over a period of time. The impact of simple deviation at the staring point is multiplied drastically. Similarly a simple flapping of a butterfly's wing at this moment produces a small wave in the atmosphere. However, over a period of time it may diverge into a Tsunami. Or, it may not. But we cannot rule out the possibility. Heard the butterfly example in Kamal Hasan's Dasavatharam? It is actually an example said by a mathematician, Edward Lorenz. 

Adam used to sleep under a coconut tree in Eden garden keeping his head towards North direction. Since some ant tasted his scalp, he changed his position and kept his head towards the south direction. On that day, a giant coconut fell over his legs. Had the ant did not bite him on that day, I would not be writing about chaos theory today. Small bite, humanity was saved. Even god is not aware of this fact. (Do you know that coconut never falls on head?!)

I like this chaos theory. We live dangerously. No rules apply here.

The Lost Tamil Continent

Well. I read few interesting books on this topic at Anna Library. A book on Tamil social history by Dr. Aravanan, ex-vice chancellor of MS univeristy, is noteworthy. The book seems to be an evidence based research work on the origin of Tamils. Though he has not provided any conclusion about the origin, he has effectively compiled most of the evidences that we have and related theories. The author's area of research is about the similarities between ancient Tamil society and the African tribes.
 
The extensive references about 'kadal konda thamizhakam' (the Tamil land engulfed by ocean) come from the treatise by Irayanar and the explanatory notes by Nakkeerar in early mediaeval period. The literary works earlier than these poets such as silappathikaram or purananooru do mention about the lost continent here and there. For example, purananooru - poem no. 9 mentions kabadapuram. Silappathikaram, while introducing the pandiyan king, mentions about the lost kingdom and the big Tsunami. I checked these two myself. The references are also found in Kalithokai and the commentaries of Adiyarkkunallar.
 
However, it is mysterious how Irayanar, a romantic poet, could get such an extensive account on the lost continent. He lists the kings and poets who were involved with the first two Tamil conventions took place in the lost continent. He mentions several poetic works of those period, which are never discovered. More importantly he gives the names of various territories in the lost continent, the rivers and the mountains. We cannot simply ignore them as a white lie or mere imagination. More or less similar data are also mentioned by Adiyarkkunallar.
 
It is also strange that Valmiki's Ramayanam (not Kambar's) mentions the name Kabadapuram. Rama instructs Hanuman to search for Sita in Srilanka and if not found, to search in Kabadapuram. This verse contains a brief description about the palaces in the city as well. The treatise by Megesthenes also has a reference to Kabadapuram and a Pandya king.
 
The most mysterious reference is about the rivers in the lost continent. One is Paktruli river and the other is Kumari river. The name, kumari river, appears in many references - just like Saraswati river in Sanskrit literature. It is ironical that the governments and universities spend plenty of resources to locate the traces of Saraswati river while no one is serious about Kumari river. Kabadapuram was said to be on the banks of Kumari river. Some of the old poems mention about taking bath in 'Kumari'. Based on the contexts, it is plausible that the Kumari did not mean the ocean at Kanyakumari, but the lost Kumari river. Taking bath in ocean had not originally been the tradition of Tamils in older days, but river bathing had been.
 
The present day Kanyakumari has a shallow water and rocky base. It could have been a mountain extension engulfed by ocean. Kumari river might have passed through this mountain. Pazhayaru could be the vestige of Kumari river, as per one writer. According to the Irayanar and Nakkeerar legends, the Pandya capitals shifted from Then Madurai to Kabadapuram to Korkai to Koodal (current Madurai). We have a documented history of Pandiya kings only from Korkai period and the history of the previous rulers is lost with the continent.

Carbon, Silicon, Life

In terms of valency, silicon resembles carbon. Both have the valency of four. However, silicon cannot substitute carbon in most of the instances from chemical or biochemical perspective. The percentage of silicon in human body is only minuscule unless we consider someone like Pamela Anderson. Next to oxygen, carbon is the most abundant element by mass in human body. Outside body - if we consider earth's crust - silicon is the most abundant element by mass next to oxygen. Thus, if carbon represents the life forms, silicon represents the non-life forms (inanimate). 

Despite the abundance of silicon in the environment, the evolutionary process has chosen carbon to develop life forms. In other words, the 3 billion years old evolutionary process has essentially discarded silicon while developing life forms. Evolution is the most intelligent phenomenon happened on earth and it has chosen carbon. Strangely our mythologies say the opposite - from clay to man! Life form can change into clay - it is scientifically possible. Petrified trees are now part of every museum, tree turned into stone, not vice versa!

Carbon is a unique element and the proteins (enzymes, muscles, etc), DNAs, hormones, neurons and almost every vital thing in our body stand as an evidence for carbon's versatility. 

Silicon cannot compete with carbon in its versatility even though mimicking our neural network using silicon should be possible at least in future. For that matter, any element which has similar conductivity properties should be able to do. People have successfully replaced silicon at least in laboratory level, for example, with molybdenum or carbon nanotubes.  I would agree that silicon may create intelligence, may be by passing Turing test. However, silicon cannot form (or be a part of) life. 

Of course, it depends on how we define life! The scientistsmay define it as a form which is self sustainable, having organic unity, reproducible and responsive to stimuli. They keep adding many other features. However, it still remains impossible to fit all life forms into these definitions and one or two forms always remain as exceptions. I wonder how these scientists forget one important phenomenon, death. They all think about sustainability ignoring the fact that destructibility is also a part of life - it is at least a part of life of all the life forms we know.

To me life is defined by death. Something that cannot die cannot be a life form. You can break a robot, but you cannot kill a robot. This definition is applicable to any life form on the earth. 

No life form can survive death. If it is the case with earth, it should be the case with the universe too. No celestial body contains any element that cannot be found on earth. Helium was first discovered on the sun, not on the earth. The discovery was made from India (but not by Indians)! The scientists thought that they had found one extraterrestrial element that was not located on earth. Later helium was also found to be available in uranium ore on earth itself. It is an example to say that the earth is the face of the universe. What we have here could be the best that the universe has offered. It will keep offering more.

SHADOWS OF MIND TO reCAPTCHA

Knowledge is infectious. When I started reading ‘Shadows of Mind: A Search for the Missing Science of Consciousness’ by Roger Penrose, the very reading took me through an interesting journey into various spheres of knowledge related to artificial intelligence.

Penrose is renowned for his work in mathematical physics. ‘Shadows of Mind’ is a sequel of his previous book, ‘The Emperor’s New Mind’. In both the books, Penrose explains inter alia the concept of ‘Turing test’. It is a test that can be used to find if a given machine thinks like a human. For example, assume that there is a machine and a human placed in front of a human judge. However, the machine, the human and the human judge are separated from each other by non-transparent sound-proof screens. The human judge knows that there is one human and one machine sitting in front of him, but he does not know which is what. The human judge has to engage in a natural language conversation with both the machine and the human and find out which is machine. The machine will try to imitate humans in its answers. The conversation is limited to text-only format (like chatting in a communicator). If the judge is not able to reliably distinguish the machine from the human, the machine is said to have passed the test. It has gained artificial intelligence!

I was curious about the Turing test and started reading other articles related to this matter. I was then introduced to another test called as ‘reverse Turing test’. It is a reverse version of Turing test in which the human judge is replaced with a machine judge. The machine judge has to find out which is machine and which is human. You may not believe that we undergo this reverse Turing test quite often when we spend our time in front of computers - especially in IP. Before we access the file wrapper from USPTOPAIR, it asks us to enter the words given in ‘reCAPTCHA’ to access the documents. I have pasted an example below:

 

The reCAPTCHA appears in many sites including social network sites. The back end machine recognizes through reCAPTCHA whether it is human or a software program (i.e. a machine) that attempts to access the web site and allows only humans because it is believed that only humans can interpret and type those distorted words correctly. The present day machines are not intelligent enough to interpret such distorted words. Thus, each time we access such web sites, we unknowingly go through a reverse Turing test!

There is an interesting story behind reCAPTCHA project. Apart from making us to undergo reverse Turing test, the reCAPTCHA indeed puts us on a job which we did not even know we had. A non-profit group called Open Content Alliance functioning from the University of Toronto is engaged in a massive project of scanning the out-of-copyright books in the world.

Once the text is scanned, the file is sent to a server in California, where it is run through optical
character recognition (OCR) software. We might have used the OCR option available in Adobe Acrobat for converting image into text. In the same way, it produces a digital full-text version of those out-ofcopyright books. However, the old text books often contain illegible words that are difficult for the software to recognize. These troublesome scans are sent on to the reCAPTCHA servers at Carnegie Mellon University in Pittsburgh.

These are the words distributed to us when we enter the sites such as USPTO. As a control, the
reCAPTCHA program distorts a known word and pairs it up with the word the scanning software has
failed to decipher. That is why we find two words in reCAPTCHA. However, we do not know which the control word is and which the original word from text book is. If we decipher the control word correctly, the computer takes our deciphering of the original text book word also as correct. However, the reCAPTCHA reconfirms it by circulating the same word few more times. It is reported that the system is now correcting over 10 million words a day, with 99.1 percent accuracy. Thus, every time we enter the web site by passing through reCAPTCHA, we actually do a job for a not-for-profit cause!

It was a long interesting journey from Shadows of Mind to reCAPTCHA.

History of the World

Religion is like human language. The similarities are inevitable. Though we have plenty of languages, many similarities could be found among them. Otherwise, it would not have been humanly possible for one man to learn other man's language. Just like language, religion must have been the product of human brains. I am reading an interesting book, "History of the world in 100 objects" by the director of British Museum.
We have discovered the items used by Homo species (may not be humans) about two million years ago. These are stone chisels discovered at a place called Olduvai in East Africa. Advance stone tools such as hand-axe have been discovered and dated to a period between 300,000 and 1 million years ago. The stone tools older than 500,000 years have been discovered only in Africa. This is one of the key evidences supporting the human origin in Africa.

Some scientists gave a stone to a man and asked him to make a stone axe. They observed which parts of his brain were active while he was chiseling. Interestingly they found that the brain region which controls our speech was also active. This study suggests that the language speaking ability for humans has evolved as early as 500,000 years ago.

The Homo sapiens anatomically similar to modern humans have evolved 250,000 - 500,000 years ago and behaviourally similar to modern humans at least 50,000 years ago. The great human migration out of Africa is believed to have happened between 100,000 BC and 50,000 BC. The stone tools made by humans have been discovered at many parts of the world in this period (including Tamil Nadu).

Why am I writing all these in relation to religion? We have discovered many items used by humans mainly stone tools and some art works with stone or tusk, which are dated to be of the period which marked human origin and migration. However, the first human articles related to any religion or worship belong to the period close to 10,000 BC! Even though humans were living, hunting, migrating and speaking for several thousand years, god seemed to have been only a late entry! Higher brain evolution, civilization and bevioral developments have been the primary requirements for religion. Baby Krishna is baby Jesus is baby Homo sapiens.

CANCER - Part II

Let me share an example from Siddhartha Mukherjee's book with few modifications. Two guys, Mr. X and Mr. Y, develop a cancer at the same in 1991. Both don't have any symptoms as the disease slowly progresses. Always cautious about health, Mr. X goes for a regular cancer screening in 1995 and diagnosed with cancer. Surgery-radiation-chemotherapy combo is performed on Mr. X. Life of Mr. X is saved for another five years due to early diagnosis and treatment. In 2000, the cancer relapses with vengeance and he dies. On the other hand, Mr. Y never cares about health and did not go for any screening. In 1999, the cancer spreads all over his body and lethal symptoms force him to be hospitalised. Surgery-radiation-chemo cycle is performed on Mr. Y in 1999. However, due to late diagnosis his life could be saved only for an year. He dies after one year of therapy, in 2000. Well. Mr. X and Mr. Y die almost on same time. However, the early diagnosis gave Mr. X five years of life and late diagnosis gave Mr. Y only an year. 

Despite the crude reality, the above example does not demean the importance of early diagnosis. Cancers like breast cancer, uterine cancer or cervical cancer can be 'completely' cured by early diagnosis. We have successfully developed methods to diagnose these cancers at very early stage. The early diagnosis in case of breast cancer has gone to the extent that the women who are genetically prone to breast cancer remove their breasts proactively, even before any possible development of cancer! Vaccination helps to prevent some cancers of viral origin.

As far as preventive life style is concerned, we know that tobacco causes cancer. Apart from tobacco, we have a laundry list of carcinogenic chemicals, but the chances of encountering them in normal life is rare. Robin Cook's 'Fever' is based on cancer due to benzene. It was a common solvent used in chemistry labs until two decades ago. It is completely out of laboratory use nowadays. Radiation and asbestos may be encountered sometimes, but highly avoidable. Alcohol is not carcinogenic, but it can be a secondary agent to lead a damaged liver to cancerous. Other than these, we are in the primitive stage to define an ideal life which may be cancer free. We could not even definitely say whether the use of cell phones causes brain cancer or not. All studies conducted in this regard have holes at the bottom. 

The first reported case of cancer was as early as 2500 BC. The Egyptian hieroglyphs mention about it. However, if we look at the history of our battle against this disease, it is not certainly a battle that we have won; neither have we lost. I haved my beloved family members succumbed to this disease. I have also seen my family members who have survived this disease. My grandmother lived for many years without any relapse. She underwent radiation therapy for uterine cancer in late 1970s at Adyar Cancer Research Institute (Chennai) and she was not under any anti-cancer medication as far as I know. She would not have taken, even if prescribed - I guess. After reading the literature on cancer, I think any oncologist would conclude that her case was a miracle. Cancer is known for its violent return after the treatment. Once relapsed, it is mostly the end. The relapse can happen after days, months or years. 

When Siddhartha Mukherjee started writing his Pulitzer winning book on cancer in mid-2004, he had also started treating an young lady, Carla, diagnosed with acute lymphoblastic leukaemia. Ninety five percent of her white blood cells were malignant, cancerous. The book naturally starts with the chapter about her arrival to hospital and the events followed by. Siddhartha had thought that the final chapter of the book would perhaps about the death of Carla. The book describes the merciless chemotherapy cycles performed on her. Siddhartha finished his book in June 2010. On the last days of completing the book, he carried out routine blood test on Carla. There was no trace of cancer, no relapse. The distinguished oncologist, Siddhartha, calls it a miracle at the last chapter of his book. However, we must not forget that there are many such miracles. 

My first - may be the last - practical acquaintance with cancer was during my post graduation when we tried to test a newly synthesised drug coupled with photo energy on cancer cell lines. The method is called photodynamic therapy whose origin may be traced back to Dracula! We all know that we need oxygen for life. How does oxygen get absorbed into our blood? You will wonder if I say it is through the rusting of our blood. The iron forms rust when it comes into contact with oxygen and water. Rust is nothing but the oxides of iron. In our blood, we have haemoglobin. At its centre, haemoglobin has a plate like molecule called porphyrin. At the centre of porphyrin, there sits an iron atom. When the blood is exposed to oxygen in our lungs, the iron atom 'rusts'. It forms an oxide like complex with oxygen. This oxygen is carried to our cells through blood. Due to some metabolic malfunction, the formation of porphyrin does not happen properly in some people. They will have defective porphyrins in their haemoglobin that cannot fit iron atom. These defective porphyrins, literally useless, are deposited by the body in the fast multiplying cells especially their skin cells. This disease is called 'porphyria'. 

Well. What is the link to Dracula and cancer?! When the skin of the porphyria affected people is exposed to sun light, the defected porphyrins deposited in the skin excite, corrode and kill the skin cells. Therefore, they cannot come our during day. They also get some tendency to drink blood which moderates the severity of the disease. Garlic increases the severity of the disease. You would have guessed it now. The scientists believe that the people with porphyria might have been called as vampires! However, this strange disease gave a clue for cancer therapy. The defective porphyrins are naturally deposited in fast multiplying cells. When exposed to light, the cells are corroded and destroyed. Since cancer has fast multiplying cells, the porphyrins can be used to kill the cancer cells. This paved way for photodynamic therapy. Porphyrin type compounds are injected to a cancer patients who have cancer in the visible areas such as skin or eye. Once the porphyrin compound is naturally deposited in the cancer cells, the cancer area is exposed to light rays. The cells get killed. This is what we tried with some porphyrin compounds synthesised at our lab. Since we cannot try on patients, we bought cancer cells and tried on them. The results were instantly perfect. However, there are several practical difficulties with this therapy which have made its application limited. A drug based on this therapy, verteporfin, is under trials for cancer treatment.

Cancer is a lucrative area for any pharmaceutical company. We have basketful of cancer drugs, but the treatment and cure are still elusive. Why? For this we need to understand the emperor of all maladies, cancer. I will write about it later.